The SPEC 2016 held in Montreal was really successful and an Analyst special SPEC 2016 issue is coming soon!
We are delighted to welcome our new PhD students:
Thomas Gladwell, Jiayi ‘Jennie’ Tang, Nga-Tsing ‘Kayto’ Tang and Widad Al Rawahi!
A. N. Keen, A. J. Fenna, J. C. McConnell, M. J. Sherratt, P. Gardner, H. A. Shiels
Frontiers in Physiology 6 (2016) 427
Chronic pressure or volume overload can cause the vertebrate heart to remodel. The hearts of fish remodel in response to seasonal temperature change. Here we focus on the passive properties of the fish heart. Building upon our previous work on thermal-remodeling of the rainbow trout ventricle, we hypothesized that chronic cooling would initiate fibrotic cardiac remodeling, with increased myocardial stiffness, similar to that seen with pathological hypertrophy in mammals. We hypothesized that, in contrast to pathological hypertrophy in mammals, the remodeling response in fish would be plastic and the opposite response would occur following chronic warming. Continue reading
Fundamental developments in infrared spectroscopic imaging for biomedical applications
Chem. Soc. Rev., 2016,45, 1935-1957
Infrared chemical imaging is a rapidly emerging field with new advances in instrumentation, data acquisition and data analysis. These developments have had significant impact in biomedical applications and numerous studies have now shown that this technology offers great promise for the improved diagnosis of the diseased state. Relying on purely biochemical signatures rather than contrast from exogenous dyes and stains, infrared chemical imaging has the potential to revolutionise histopathology for improved disease diagnosis. In this review we discuss the recent advances in infrared spectroscopic imaging specifically related to spectral histopathology (SHP) and consider the current state of the field. Finally we consider the practical application of SHP for disease diagnosis and consider potential barriers to clinical translation highlighting current directions and the future outlook.