SPEC 2014!
SPEC 2014, Shedding new Light on Disease will be held in Krakow, Poland, 17-22 August 2014. For more information visit the official website of the conference: SPEC 2014
SPEC 2012
The Gardner group made an impact on the SPEC 2012 conference in Chiang Mai with five oral presentations and three posters. The presentations were well received, although Peter may have disappointed some of the audience by showing how their transflection mode data is seriously flawed (see our paper on the subject).
HOT Paper!
Our article on Highlighting a need to distinguish cell cycle signatures from cellular responses to chemotherapeutics in SR-FTIR spectroscopy by Caryn, Frank, Geri and Peter, together with Mick Brown and Noel Clarke from the Paterson Institute for Cancer Research and Kevin Flower from the School of Chemistry, has been awarded Hot Paper status by Analyst. The article is free to read until 30 November 2012. Reference: Highlighting a need to distinguish cell cycle signatures from cellular responses to chemotherapeutics in SR-FTIR…
Paper – Rare sub-variants of bladder cancer
FTIR microspectroscopy of selected rare diverse sub-variants of carcinoma of the urinary bladder Caryn Hughes, Junaid Iqbal-Wahid, Michael Brown, Jonathan H. Shanks, Amanda Eustace, Helen Denley, Peter J. Hoskin, Catharine West, Noel W. Clarke, Peter Gardner Journal of Biophotonics (2012) Abstract Urothelial carcinomas of the bladder are a heterogeneous group of tumours, although some histological sub-variants are rare and sparsely reported in the literature. Diagnosis of sub-variants from conventional urothelial carcinoma can be challenging, as they may mimic the morphology…
Paper – Problems with transflection-mode IR
The inherent problem of transflection-mode infrared spectroscopic microscopy and the ramifications for biomedical single point and imaging applications Paul Bassan, Joe Lee, Ashwin Sachdeva, Juliana Pissardini, Konrad M. Dorling, John S. Fletcher, Alex Henderson and Peter Gardner Analyst, 2013, 138, 144-157 Abstract Transflection-mode FTIR spectroscopy has become a popular method of measuring spectra from biomedical and other samples due to the relative low cost of substrates compared to transmission windows, and a higher absorbance due to a double pass through…
Paper – Cell cycle using a synchrotron
Highlighting a need to distinguish cell cycle signatures from cellular responses to chemotherapeutics in SR-FTIR spectroscopy C. Hughes, M. D. Brown, F. J. Ball, G. Monjardez, N. W. Clarke, K. R. Flower and P. Gardner Analyst 137 (2012) 5736-5742 Abstract Previous research has seen difficulties in establishing clear discrimination by principal component analysis (PCA) between drug-treated cells analysed by single point SR-FTIR spectroscopy, relative to multisampling cell monolayers by conventional FTIR. It is suggested that the issue arises due to…
Welcome Adam!
Today we welcome a new student – Adam Keen. Adam will be working on a joint project with Dr Holly Shiels in the Faculty of Life Sciences studying the mechanisms involved in vertebrate heart operation.
Paper – Synchrotron IR for chemotherapeutics in renal cell carcinoma
Investigating cellular responses to novel chemotherapeutics in renal cell carcinoma using SR-FTIR spectroscopy C. Hughes, M. D. Brown, N. W. Clarke, K. R. Flower and P. Gardner Analyst 137 (2012) 4720-4726 Abstract SR-FTIR spectroscopy was evaluated as a technique to discriminate spectral signals of cellular response at the single cell level, when cancer cells are exposed to chemotherapeutics. 5-Fluorouracil, an established drug of known mode of action, was tested against a renal carcinoma cell line (Caki-2), along with two experimental…
Welcome!
Welcome to the website of the Gardner Lab. The group is headed by Professor Peter Gardner who has 25 years of research experience in the field of vibrational spectroscopy. For the last 10 years the group has focused on the development of vibrational and related spectroscopies for biomedical applications with a particular interest in cancer diagnosis. Here you can find out more about group members, the group’s activities, current research, and PhD studentships. There are also conference reports and news…
Article – Spectroscopy in biomedical research
Spectroscopy: Infrared and Raman spectroscopy in biomedical research, Innovation into Success P. Gardner The Quarterly Journal of UKSPA 29 (2012) 23