James studied Chemical Engineering at the University of Manchester from 2010 to 2014, obtaining a 2:1 Masters of Engineering. During his final year, James worked under the supervision of Professor Gardner on his dissertation project, investigating drug resistance in renal cell carcinoma (RCC) using infrared spectroscopy.

After graduating, James returned to the group in September 2014 as a PhD research student, working in collaboration with Dr Gianfelice Cinque from the Diamond Light Source synchrotron in Didcot, Oxfordshire. James’ project focuses on the development of experimental and data processing methods for live cell infrared imaging, as well as continuing work on drug resistance in RCC. James has also collaborated with Professor Maria Marques from the University of Coimbra, Portugal, on her work investigating the effects of chemotherapy drugs on breast cancer cells.

Publications

5	Live single cell analysis using synchrotron FTIR microspectroscopy: development of a simple dynamic flow system for prolonged sample viability James Doherty, Alan Raoof, Ansaf Hussain, Magda Wolna, Gianfelice Cinque, Michael Brown, Peter Gardner and Joanna Denbigh Analyst 144 (2019) 997-1007
4	Anticancer drug impact on DNA – a study by neutron spectroscopy coupled with synchrotron-based FTIR and EXAFS Ana L. M. Batista de Carvalho, Adriana P. Mamede, Asha Dopplapudi, Victoria Garcia Sakai, James Doherty, Mark Frogley, Gianfelice Cinque, Peter Gardner, Diego Gianolio, Luís A. E. Batista de Carvalho and M. Paula M. Marques Physical Chemistry Chemical Physics 21 (2019) 4162-4175
3	Increased optical pathlength through aqueous media for the infrared microanalysis of live cells James Doherty, Zhe Zhang, Katia Wehbe, Gianfelice Cinque, Peter Gardner and Joanna Denbigh Analytical and Bioanalytical Chemistry 410(23) (2018) 5779–5789
2	Single cell analysis using Fourier transform infrared microspectroscopy James Doherty, Gianfelice Cinque and Peter Gardner Applied Spectroscopy Reviews 52(6) (2017) 560-587
1	Chemotherapeutic Response to Cisplatin-like Drugs in Human Breast Cancer Cells Probed by Vibrational Microspectroscopy Ana L. M. Batista de Carvalho, Mike Pilling, Peter Gardner, James Doherty, Gianfelice Cinque, Katia Wehbe, Chris Kelley, Luis A. E. Batista de Carvalho and Maria Paula M Marques Faraday Discuss. 187 (2016) 273-298