SPEC 2016 – ANALYST SPECIAL SPEC 2016 ISSUE
The SPEC 2016 held in Montreal was really successful and an Analyst special SPEC 2016 issue is coming soon!
Welcome!
We are delighted to welcome our new PhD students: Thomas Gladwell, Jiayi ‘Jennie’ Tang, Nga-Tsing ‘Kayto’ Tang and Widad Al Rawahi!
Paper – The Dynamic Nature of Hypertrophic and Fibrotic Remodeling of the Fish Ventricle
The Dynamic Nature of Hypertrophic and Fibrotic Remodeling of the Fish Ventricle A. N. Keen, A. J. Fenna, J. C. McConnell, M. J. Sherratt, P. Gardner, H. A. Shiels Frontiers in Physiology 6 (2016) 427 doi: 10.3389/fphys.2015.00427 Abstract Chronic pressure or volume overload can cause the vertebrate heart to remodel. The hearts of fish remodel in response to seasonal temperature change. Here we focus on the passive properties of the fish heart. Building upon our previous work on thermal-remodeling of the rainbow trout ventricle, we…
Review Paper – Fundamental Developments in IR Spectroscopic Imaging for Biomedical Applications
Fundamental developments in infrared spectroscopic imaging for biomedical applications Michael Pilling and Peter Gardner Chem. Soc. Rev., 2016,45, 1935-1957 DOI: 10.1039/C5CS00846H Abstract Infrared chemical imaging is a rapidly emerging field with new advances in instrumentation, data acquisition and data analysis. These developments have had significant impact in biomedical applications and numerous studies have now shown that this technology offers great promise for the improved diagnosis of the diseased state. Relying on purely biochemical signatures rather than contrast from exogenous dyes and stains, infrared…
Paper – Chemotherapeutic Response in Human Breast Cancer Cells
Chemotherapeutic response to cisplatin-like drugs in human breast cancer cells probed by vibrational microspectroscopy A. L. M. Batista de Carvalho, M. Pilling, P. Gardner, J. Doherty, G. Cinque, K. Wehbe, C. Kelley, L. A. E. Batista de Carvalho and M. P. M. Marques Faraday Discuss., 2016,187, 273-298 DOI: 10.1039/C5FD00148J Abstract Studies of drug–cell interactions in cancer model systems are essential in the preclinical stage of rational drug design, which relies on a thorough understanding of the mechanisms underlying cytotoxic activity and biological effects, at a molecular level….
Paper – High-Throughput QCL Spectral Histopathology
High-throughput quantum cascade laser (QCL) spectral histopathology: a practical approach towards clinical translation M. J. Pilling, A. Henderson, B. Bird, M. D. Brown, N. W. Clarke and P. Gardner Faraday Discuss., 2016,187, 135-154 DOI: 10.1039/C5FD00176E Abstract Infrared microscopy has become one of the key techniques in the biomedical research field for interrogating tissue. In partnership with multivariate analysis and machine learning techniques, it has become widely accepted as a method that can distinguish between normal and cancerous tissue with both high sensitivity and high specificity. While…
Paper – Laser Tweezers Raman Spectroscopy
Automated analysis of single cells using Laser Tweezers Raman Spectroscopy S. Casabella, P. Scully, N. Goddard and P. Gardner Analyst, 2016, Advance Article DOI: 10.1039/C5AN01851J
Paper – Cell cytotoxicity
Characterising cytotoxic agent action as a function of the cell cycle using fourier transform infrared microspectroscopy M. Jimenez-Hernandez, M.D. Brown, C. Hughes, N.W. Clarke and P. Gardner Analyst (2015)
Paper – Bench-top, high mag. imaging
Enhanced FTIR benchtop imaging of single biological cells Caryn Hughes, Alex Henderson, Mustafa Kansiz, Konrad Dorling, Melody Jimenez-Hernandez, Michael D Brown, Noel William Clarke and Peter Gardner Analyst 140 (2015) 2080-2085
Paper – Transmission versus transflectance FTIR
Comparison of transmission and transflectance mode FTIR imaging of biological tissue Michael J. Pilling, Paul Bassan and Peter Gardner Analyst (2015)